Amorolfine is used
in the treatment of fungal nail infections and fungal skin infections.
AVAILABLE IN JAN
AUSHADHI KOTTIYAM- PRICE -RS 55
Amorolfine (or
amorolfin), is a morpholine antifungal drug that inhibits Delta14-sterol
reductase-sterol and cholestenol Delta-isomerase, which depletes ergosterol and
causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.
Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly
available in the form of a nail lacquer, containing 5% amorolfine hydrochloride
as the active ingredient. It is used to treat onychomycosis (fungal infection
of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or
twice-weekly applications has been shown in two studies to be between 60% and
71% effective in treating toenail onychomycosis; complete cure rates three
months after stopping treatment (after six months of treatment) were 38% and
46%. However, full experimental details of these trials were not available and
since they were first reported in 1992 there have been no subsequent trials.
It is a topical
solution for the treatment of toenail infections.Systemic treatments may be
considered more effective.
How Amorolfine
works
Amorolfine is an
antifungal medication. It works by preventing fungi from producing ergosterol,
an essential component of fungal cell membranes. Without ergosterol, the fungi
stop growing and its cells breakdown. Gradually, the infected nail grows out,
until only healthy nail is left.
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