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Tuesday, January 11, 2022



Amorolfine is used in the treatment of fungal nail infections and fungal skin infections.




Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits Delta14-sterol reductase-sterol and cholestenol Delta-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine hydrochloride as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications has been shown in two studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment (after six months of treatment) were 38% and 46%. However, full experimental details of these trials were not available and since they were first reported in 1992 there have been no subsequent trials.


It is a topical solution for the treatment of toenail infections.Systemic treatments may be considered more effective.

How Amorolfine works

Amorolfine is an antifungal medication. It works by preventing fungi from producing ergosterol, an essential component of fungal cell membranes. Without ergosterol, the fungi stop growing and its cells breakdown. Gradually, the infected nail grows out, until only healthy nail is left.


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