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Sunday, May 30, 2021

TOLVAPTAN 15 MG TAB

 


                                                  JAN AUSHADHI KOTTIYAM PRICE  RS 210 FOR 10 TAB

                 Tolvaptan is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan was approved by the U.S. Food and Drug Administration (FDA) on May 19, 2009. Tolvaptan, as Jynarque, was granted approval for medical use in the United States in April 2018.

The U.S. Food and Drug Administration (FDA) granted tolvaptan a fast track designation for clinical trials investigating its use for the treatment of polycystic kidney disease. The FDA granted Jynarque an orphan drug designation in April 2012, for the treatment of autosomal dominant polycystic kidney disease.

 Tolvaptan is available as a generic medication.



                                                                                  C26H25ClN2O3

Use

Tolvaptan (Samsca) is indicated for the treatment of clinically significant hypervolemic and euvolemic hyponatremia.

Tolvaptan (Jynarque) is indicated to slow kidney function decline in adults at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD).

 

Side effects

The FDA has determined that tolvaptan should not be used for longer than 30 days and should not be used in patients with underlying liver disease because it can cause liver injury, potentially leading to liver failure. When using to treat hyponatremia, it may cause too rapid correction of hyponatremia resulting in fatal osmotic demyelination syndrome.

 



Bacillus Clausii Spores Suspension

 


Available at JAN AUSHADHI KOTTIYAM - 15 RS

      Probiotic for kids that contains Bacillus Clausii, friendly bacteria normally present in the gut that turns unhappy tummies to happy ones. The bacteria maintain a healthy relationship with the body such that there are no side effects or any major issues. It has a symbiotic relationship with the host organism which ensures a win-win situation for both.

It is used to treat diarrhea in children. It is known to strengthen immunity in kids by improving their intestinal health. It also helps to treat chronic diarrhea in adults. It is used to treat any changes of the intestinal bacterial flora and maintain the right equilibrium of the gut bacteria. It helps to correct consequent dysvitaminosis, a condition that causes an imbalance of vitamins either in their production or absorption in the body.

 

It contains 2 billion spores of poly-antibiotic resistant Bacillus clausii. It helps to treat and prevent diarrhea associated with excessive use of antibiotics. Along with that, it is equally efficient in the treatment as well as prevention of diarrhea caused by various infections. It helps in restoring the normal microbial flora of the intestine.

 

It helps to increase the absorption of nutrients by improving the number of good bacteria in the intestine. It also helps in recovery in conditions that are caused due to infections in the intestines and antibiotic usage that disrupt the natural microflora present in the gut. It also benefits people who experience flatulence and gastrointestinal problems such as irregular bowel movements.

 

It is advised to take it as directed by your doctor. If you are taking this along with antibiotics, make sure to maintain the time gap of at least 2 hours for effective results. It usually does not cause any side effects when taken as recommended by your doctor. However, in case you experience any symptoms or side effects, then it is wise to get in touch with your doctor.

Antibiotics kill bacteria including the friendly ones in the stomach that are essential for digestion & food absorption. It restores the balance of friendly bacteria in intestines, increases absorption of nutrients by the body, and increases body's ability to resist microbial attacks.

Helps in treating chronic diarrhea

Useful in treating infection in the intestine

Treats the imbalance of production and absorption of vitamins

Helps to strengthen the child's immunity and provides gentle gut care

Provides relief from chronic gastrointestinal disorders

Directions for use:

Use as directed by your physician. Ideally, it is advised that adults can consume 2 to 3 mini bottles a day whereas children can take 1 to 2 mini bottles a day


Saturday, May 29, 2021

RIVAROXABAN TAB

 


 

 

 Rivaroxaban is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. It is taken by mouth.



Available in JAN AUSHADHI STORE KOTTIYAM - 210 RS FOR 30 TABLETS (7RS)




 C19H18ClN3O5S

Common side effects include bleeding. Other serious side effects may include spinal hematoma and anaphylaxis. It is unclear if use in pregnancy and breastfeeding is safe. Compared to warfarin it has fewer interactions with other medications. It works by blocking the activity of the clotting protein factor Xa.

 

Rivaroxaban was patented in 2007 and approved for medical use in the United States in 2011. In the United States, it will not be available as a generic medication until 2024. In 2018, it was the 100th most commonly prescribed medication in the United States, with more than 7 million prescriptions.

USES     -    In those with non-valvular atrial fibrillation, it appears to be as effective as warfarin in preventing ischemic strokes and embolic events. Rivaroxaban is associated with lower rates of serious and fatal bleeding events than warfarin, though rivaroxaban is associated with higher rates of bleeding in the gastrointestinal tract. 

In July 2012, the UK's National Institute for Health and Clinical Excellence recommended rivaroxaban to prevent and treat venous thromboembolism.


MECHANISM OF ACTION

Rivaroxaban inhibits both free Factor Xa and Factor Xa bound in the prothrombinase complex. It is a highly selective direct Factor Xa inhibitor with a rapid onset of action. Inhibition of Factor Xa interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade, inhibiting both thrombin formation and development of thrombi. Rivaroxaban does not inhibit thrombin (activated Factor II), and no effects on platelets have been demonstrated. It allows predictable anticoagulation and dose adjustments and routine coagulation monitoring; dietary restrictions are not needed. 

Unfractionated heparin (UFH), low molecular weight heparin (LMWH), and fondaparinux also inhibit the activity of factor Xa, indirectly, by binding to circulating antithrombin (AT III) and must be injected, whereas the orally active warfarin, phenprocoumon, and acenocoumarol are vitamin K antagonists (VKA), decreasing a number of coagulation factors, including Factor X. 

Rivaroxaban has predictable pharmacokinetics across a wide spectrum of patients (age, gender, weight, race) and has a flat dose response across an eightfold dose range (5–40 mg). The oral bioavailability decreases with higher doses and increases when taken with food.

OTHER BRANDS




Friday, January 1, 2021

Jan Aushadhi PROTEIN BAR

 


Protein bars are a type of nutritional supplement and have a good balance of carbohydrates, protein and fat. PMBJP brings you Jan Aushadhi Chocolate Protein Bar at just Rs 40/- per bar. Visit your nearest JanAushadhi Kendra today.  

AVAILBLE STORES 

JAN AUSHADHI KOTTIYAM

JAN AUSHADHI KANNANALLOOR

JAN AUSHADHI MAYYANADU

IMMUNITY BAR

 



Chocolate for Children and Adults

Giving a boost to your immunity, PMBJP brings you Jan Aushadhi Immunity Bar at just Rs.10/- per bar






SALBUTAMOL INHALER




Salbutamol is used to relieve symptoms of asthma and chronic obstructive pulmonary disease (COPD) such as coughing, wheezing and feeling breathless. It works by relaxing the muscles of the airways into the lungs, which makes it easier to breathe.

Salbutamol is sometimes given as tablets, capsules or syrup for people who cannot use an inhaler very well.

It can also be given using a nebuliser, but this is usually only if you have severe asthma or COPD. A nebuliser is a machine that helps you breathe in your medicine as a mist, using a mask or a mouthpiece. You can use a nebuliser in hospital or you may be given one to manage your condition at home.

This medicine is only available on prescription.




 Key facts

Salbutamol inhalers are safe and effective with few side effects if you use them as advised by your doctor, pharmacist or nurse.

Salbutamol inhalers are called "reliever" inhalers because they give you quick relief from breathing problems when you need it. In most cases, you will be given another inhaler to "prevent" your symptoms and you should use this regularly every day.

If you need to use your salbutamol inhaler more than 3 times a week, it could be a sign that your breathing problem is not well controlled. Talk to your doctor, pharmacist or nurse.

Salbutamol is safe to use in pregnancy and while breastfeeding.

Who can and cannot use salbutamol inhalers

Salbutamol can be used by adults and children of all ages.

Salbutamol is not suitable for people with certain health problems.

Check with your doctor before starting salbutamol if you:


have had an allergic reaction to salbutamol or any other medicines in the past

take other medicines including ones you buy from a pharmacy, herbal remedies or supplements

have a rare inherited digestive disorder of galactose intolerance, the Lapp lactase deficiency or glucose-galactase malabsorption. This is because many salbutamol products contain lactose. Do not have lactose if you have these conditions

If you have a lactose intolerance, however, the amount of lactose in salbutamol products is too small to cause you any problems.


 How and when to use your inhaler

Only use your salbutamol when you need it. This may be when you notice symptoms, such as coughing, wheezing, shortness of breath and tightness in the chest or you know that you are going to do an activity that can make you breathless, for example climbing stairs or sport. You should feel a difference to your breathing within a few minutes.


The normal way for adults and children to use their inhaler is:


1 or 2 puffs of salbutamol when you need it

up to a maximum of 4 times in 24 hours (regardless of whether you have 1 puff or 2 puffs at a time)

Salbutamol is sometimes prescribed to prevent breathing symptoms happening in the first place. This could be before a trigger such as exercise or exposure to pets. In this situation, the normal dose is still 1 or 2 puffs at a time.


If you need to use your inhaler more than 4 times in 24 hours:


it may mean that your health problem is getting worse and that you need different treatment

you are more likely to get side effects such as increased heart rate, jitteriness, nervousness and headaches

Make an appointment to see your doctor, pharmacist or nurse if you need to use your inhaler:


more than 4 times in 24 hours

more than 2 days of each week

in the middle of the night at least once a week

During an asthma attack

In a sudden asthma attack you can use your inhaler more and take up to 10 puffs. Wait 30 seconds and always shake the inhaler between doses. You can repeat this dose 10 minutes later.