TOLVAPTAN 15 MG TAB

 

                                                  JAN AUSHADHI KOTTIYAM PRICE  RS 210 FOR 10 TAB

                 Tolvaptan is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan was approved by the U.S. Food and Drug Administration (FDA) on May 19, 2009. Tolvaptan, as Jynarque, was granted approval for medical use in the United States in April 2018.

The U.S. Food and Drug Administration (FDA) granted tolvaptan a fast track designation for clinical trials investigating its use for the treatment of polycystic kidney disease. The FDA granted Jynarque an orphan drug designation in April 2012, for the treatment of autosomal dominant polycystic kidney disease.

 Tolvaptan is available as a generic medication.

                                                                                  C₂₆H₂₅ClN₂O₃

Use

Tolvaptan (Samsca) is indicated for the treatment of clinically significant hypervolemic and euvolemic hyponatremia.

Tolvaptan (Jynarque) is indicated to slow kidney function decline in adults at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD).

 

Side effects

The FDA has determined that tolvaptan should not be used for longer than 30 days and should not be used in patients with underlying liver disease because it can cause liver injury, potentially leading to liver failure. When using to treat hyponatremia, it may cause too rapid correction of hyponatremia resulting in fatal osmotic demyelination syndrome.

 

Bacillus Clausii Spores Suspension

 

Available at JAN AUSHADHI KOTTIYAM - 15 RS

      Probiotic for kids that contains Bacillus Clausii, friendly bacteria normally present in the gut that turns unhappy tummies to happy ones. The bacteria maintain a healthy relationship with the body such that there are no side effects or any major issues. It has a symbiotic relationship with the host organism which ensures a win-win situation for both.

It is used to treat diarrhea in children. It is known to strengthen immunity in kids by improving their intestinal health. It also helps to treat chronic diarrhea in adults. It is used to treat any changes of the intestinal bacterial flora and maintain the right equilibrium of the gut bacteria. It helps to correct consequent dysvitaminosis, a condition that causes an imbalance of vitamins either in their production or absorption in the body.

 

It contains 2 billion spores of poly-antibiotic resistant Bacillus clausii. It helps to treat and prevent diarrhea associated with excessive use of antibiotics. Along with that, it is equally efficient in the treatment as well as prevention of diarrhea caused by various infections. It helps in restoring the normal microbial flora of the intestine.

 

It helps to increase the absorption of nutrients by improving the number of good bacteria in the intestine. It also helps in recovery in conditions that are caused due to infections in the intestines and antibiotic usage that disrupt the natural microflora present in the gut. It also benefits people who experience flatulence and gastrointestinal problems such as irregular bowel movements.

 

It is advised to take it as directed by your doctor. If you are taking this along with antibiotics, make sure to maintain the time gap of at least 2 hours for effective results. It usually does not cause any side effects when taken as recommended by your doctor. However, in case you experience any symptoms or side effects, then it is wise to get in touch with your doctor.

Antibiotics kill bacteria including the friendly ones in the stomach that are essential for digestion & food absorption. It restores the balance of friendly bacteria in intestines, increases absorption of nutrients by the body, and increases body's ability to resist microbial attacks.

Helps in treating chronic diarrhea

Useful in treating infection in the intestine

Treats the imbalance of production and absorption of vitamins

Helps to strengthen the child's immunity and provides gentle gut care

Provides relief from chronic gastrointestinal disorders

Directions for use:

Use as directed by your physician. Ideally, it is advised that adults can consume 2 to 3 mini bottles a day whereas children can take 1 to 2 mini bottles a day

RIVAROXABAN TAB

 

 

 

 Rivaroxaban is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. It is taken by mouth.

Available in JAN AUSHADHI STORE KOTTIYAM - 210 RS FOR 30 TABLETS (7RS)

 C₁₉H₁₈ClN₃O₅S

Common side effects include bleeding. Other serious side effects may include spinal hematoma and anaphylaxis. It is unclear if use in pregnancy and breastfeeding is safe. Compared to warfarin it has fewer interactions with other medications. It works by blocking the activity of the clotting protein factor Xa.

 

Rivaroxaban was patented in 2007 and approved for medical use in the United States in 2011. In the United States, it will not be available as a generic medication until 2024. In 2018, it was the 100th most commonly prescribed medication in the United States, with more than 7 million prescriptions.

USES     -    In those with non-valvular atrial fibrillation, it appears to be as effective as warfarin in preventing ischemic strokes and embolic events. Rivaroxaban is associated with lower rates of serious and fatal bleeding events than warfarin, though rivaroxaban is associated with higher rates of bleeding in the gastrointestinal tract. 

In July 2012, the UK's National Institute for Health and Clinical Excellence recommended rivaroxaban to prevent and treat venous thromboembolism.

MECHANISM OF ACTION

Rivaroxaban inhibits both free Factor Xa and Factor Xa bound in the prothrombinase complex. It is a highly selective direct Factor Xa inhibitor with a rapid onset of action. Inhibition of Factor Xa interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade, inhibiting both thrombin formation and development of thrombi. Rivaroxaban does not inhibit thrombin (activated Factor II), and no effects on platelets have been demonstrated. It allows predictable anticoagulation and dose adjustments and routine coagulation monitoring; dietary restrictions are not needed. 

Unfractionated heparin (UFH), low molecular weight heparin (LMWH), and fondaparinux also inhibit the activity of factor Xa, indirectly, by binding to circulating antithrombin (AT III) and must be injected, whereas the orally active warfarin, phenprocoumon, and acenocoumarol are vitamin K antagonists (VKA), decreasing a number of coagulation factors, including Factor X. 

Rivaroxaban has predictable pharmacokinetics across a wide spectrum of patients (age, gender, weight, race) and has a flat dose response across an eightfold dose range (5–40 mg). The oral bioavailability decreases with higher doses and increases when taken with food.

OTHER BRANDS