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Saturday, October 14, 2017

DIACEREIN 50


JAN AUSHADHI KOTTIYAM PRICE - RS - 36.11 / 10 CAP

Diacerein blocks the chemicals that cause inflammation and pain. It builds cartilage (the hard connective tissue in the bones near the joints) in the body.

Diacerein is also known as diacetylrhein, is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis (swelling and pain in the joints).It works by inhibiting interleukin-1 beta. An updated 2014 Cochrane review found diacerein had a small beneficial effect on pain.Diacerein-containing medications are registered in some European Union and Asian countries and included as a treatment option on several international therapeutic guidelines.

PHARMACOLOGY
 Diacerein works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that play a role in the development of symptoms of degenerative joint diseases such as osteoarthritis. Due to its specific mode of action, which does not involve the inhibition of prostaglandin synthesis, diacerein has been shown to have anti-osteoarthritis and cartilage stimulating properties in vitro and animal models.

 DOSAGE AND ADMINISTRATION
The recommended starting dose is 50 mg once daily with evening meal for the first 2 to 4 weeks of treatment, after which the recommended daily dose is 50mg twice daily.The treatment should be taken with food, one with breakfast and the other with evening meal. The capsules must be swallowed intact, without opening them, together with a glass of water.

Special Warning
In 2014 the European Medicines Agency (EMA’s) Pharmacovigilance and Risk Assessment Committee (PRAC) performed a review of diacerein-containing medicines over concerns about its gastrointestinal and liver effects. As a result, the PRAC has introduced additional proposals to manage diacerein’s risks and was satisfied that with new restrictions diacerein’s benefit on pain outweighs the side effects for osteoarthritis treatment.The following recommendations have been made around the use of diacerein:

    Due to the potential complications that can occur as a result of diarrhea in older adults, diacerein is no longer recommended in patients aged 65 years and above.
    It is also advised that patients start treatment on half the normal dose (i.e. 50 mg daily instead of 100 mg daily), and should stop taking diacerein if diarrhea occurs.
    It should not be used in any patient with liver disease or a history of liver disease, and doctors should be monitoring their patients for early signs of liver problems.
    The use of diacerein is to be limited to treating symptoms of osteoarthritis affecting the hip or knee.
    Diacerein should not be administered during pregnancy and lactation.

The PRAC concluded that the benefit-risk balance of diacerein-containing medicinal products remained favourable in the symptomatic treatment osteoarthritis, subject to the agreed changes to the product information and conditions.

 

BRAND

COMPANY

MRP For 10 S

JAS KOTTIYAM JAN USHADHI KOTTIYAM 36.11
DYCERIN 50GLENMARK 101.60
ARTHOCERIN 50 PULSE 79.00
ORCERIN 50 MACLEODS 87.70
OSTEOGARD 50 MICRO 90.00
DURAJOINT 50 ABOTT 91.00

C19H12O8
 Diacetylrhein; Diacerhein;



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